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Genetic and Environmental Factors Genetics Genetic causes of obesity may derive from monogenic or polygenic hypothalamic defects resulting in impairment in the ability of the hypothalamic circuitry to regulate body weight by controlling energy expenditure, food intake and some peripheral metabolic actions

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The hepatitis C virus core protein inhibits adipose triglyceride lipase (ATGL)-mediated lipid mobilization and enhances the ATGL interaction with comparative gene identification 58 (CGI-58) and lipid droplets